Table 3 Multivariate competing risk regression analysis for local recurrence and distant metastasis, with death as competing event.

From: T-regulatory cells predict clinical outcome in soft tissue sarcoma patients: a clinico-pathological study

Multivariate analysis

Local recurrence

Distant metastasis

 

Overall survival

 

HR (95% CI)

p Value

HR (95% CI)

p Value

HR (95% CI)

p Value

Age at surgery (years)

    

1.03 (1.02–1.05)

<0.001

R1/2 margins (vs. R0 as ref.)

2.14 (0.94–4.89)

0.072

    

G1 (ref.)

  

1

   

 G2

  

2.69 (0.66–11.03)

0.169

  

 G3

  

2.68 (0.69–10.39)

0.153

  

Tumour size (cm)

  

1.06 (1.02–1.11)

0.003

1.04 (0.99–1.08)

0.076

MF (ref.)

  

1

   

 SS

  

1.72 (0.59–5.01)

0.321

  

 UPS

  

2.69 (1.29–5.62)

0.008

  

 LPS

  

0.48 (0.17–1.35)

0.163

  

 Other

  

1.57 (0.66–3.75)

0.307

  

 LMS

  

2.16 (1.07–4.33)

0.031

  

CD3+CD4+FOXP3+ Tregs

1.41 (1.08–1.59)

0.006

    

FOX3P+ cells

    

0.98 (0.96–1.01)

0.076

CD3−PD-L1+ cells

    

1.12 (0.98–1.27)

0.087

  1. Multivariate Cox regression analysis for overall survival.
  2. P values in bold highlight significant results.
  3. TILs tumour-infiltrating lymphocytes, MFS myxofibrosarcoma, SS synovial sarcoma, UPS undifferentiated pleomorphic sarcoma, LPS liposarcoma, LMS leiomyosarcoma.
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