Fig. 2: Kaplan–Meier plot with time from surgery on the x axis and estimated overall survival or disease free survival on the y axis. | British Journal of Cancer

Fig. 2: Kaplan–Meier plot with time from surgery on the x axis and estimated overall survival or disease free survival on the y axis.

From: Impact of KRAS, BRAF and microsatellite instability status after cytoreductive surgery and HIPEC in a national cohort of colorectal peritoneal metastasis patients

Fig. 2

a Overall survival after CRS-HIPEC based on mutation status. The blue line represents the KRAS-mutated tumours (mutKRAS) tumours and the green dotted line represents the BRAF-mutated (mutBRAF) tumours. The gold dashed line represents the patients with KRAS and BRAF wild-type (double wt) tumours. Log-rank test shows significant difference between mutBRAF vs mutKRAS, P = 0.046 and between mutBRAF vs double wt, P < 0.001. b Disease-free survival after CRS-HIPEC based on mutation status. Kaplan–Meier plot with time from surgery on the x axis and estimated overall survival on the y axis. The blue line represents the KRAS-mutated tumours (mutKRAS) and the green dotted line represents the BRAF-mutated (mutBRAF) tumours. The gold dashed line represents the patients with KRAS and BRAF wild-type (double wt) tumours. Log-rank test is ns. c Overall survival comparing mutation and microsatellite instability (MSI) status. Kaplan–Meier plot with time from surgery on the x axis and estimated overall survival on the y axis. The blue line represents the KRAS-mutated tumours (mutKRAS) tumours and the green dotted line represents the BRAF-mutated microsatellite stable (MSS) (mutBRAF/MSS) tumours. The gold dashed line represents the patients with KRAS and BRAF wild-type (double wt) tumours and the black dashed/dotted line represents the BRAF-mutated microsatellite instable (MSI (mutBRAF/MSI) tumours. Log-rank test shows a significant difference between mutBRAF groups with MSI or MSS with P = 0.022. d Disease-free survival after CRS-HIPEC based on mutation and microsatellite instability (MSI) status. Kaplan–Meier plot with time from surgery on the x axis and estimated overall survival on the y axis. The blue line represents the KRAS-mutated tumours (mutKRAS) tumours and the grey dotted line represents the BRAF-mutated microsatellite stable (MSS) (mutBRAF/MSS) tumours. The gold dashed line represents the patients with KRAS and BRAF wild-type (double wt) tumours and the black dashed/dotted line represents the BRAF-mutated microsatellite instable (MSI) (mutBRAF/MSI) tumours. Log-rank test shows a significant difference between mutBRAF/MSI group and mutKRAS group with P = 0.049.

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