Table 1 Results of PheWAS and effect estimates of the comparison between the top risk quartile and the bottom risk quartile.
Description | Correspond ICD10 codes | Group | Number of participants | Number of cases | Beta | SE | FDR q | OR (95% CI)a | Pa |
|---|---|---|---|---|---|---|---|---|---|
Benign neoplasm of colon | D12, K63.5 | Neoplasms | 334,134 | 18,796 | 0.46 | 0.01 | 3.94 × 10−251 | 1.93 (1.85, 2.01) | 3.59 × 10−201 |
Benign neoplasm of unspecified sites | D10–D36 | Neoplasms | 334,385 | 40,252 | 0.18 | 0.01 | 2.09 × 10−76 | 1.29 (1.25, 1.33) | 1.05 × 10−63 |
Anal and rectal polyp | K62.0, K62.1 | Digestive | 268,006 | 6807 | 0.37 | 0.02 | 2.43 × 10−61 | 1.66 (1.54, 1.78) | 9.06 × 10−47 |
Malignant neoplasm, otherb | B21.7, C00–C97, D00–D48, M90.7 | Neoplasms | 328,419 | 91,309 | 0.09 | 0.01 | 2.60 × 10−34 | 1.13 (1.11, 1.16) | 1.67 × 10−29 |
Other disorders of intestine | K00–K14, K55–K63, K92.8, K92.9 | Digestive | 332,441 | 71,242 | 0.09 | 0.01 | 6.12 × 10−21 | 1.13 (1.10, 1.16) | 5.36 × 10−25 |
Diverticular disease | K57 | Digestive | 298,598 | 27,266 | 0.12 | 0.01 | 4.02 × 10−22 | 1.18 (1.14, 1.22) | 2.48 × 10−20 |
Neoplasm of unspecified nature of digestive system | D37 | Neoplasms | 323,276 | 953 | 0.39 | 0.06 | 2.19 × 10−9 | 1.91 (1.59, 2.30) | 3.25 × 10−12 |
Malignant neoplasm of other and ill-defined sites within the digestive organs and peritoneum | C26.1, C26.8, C26.9, D01, D01.7, D01.9 | Neoplasms | 324,092 | 1769 | 0.23 | 0.04 | 1.71 × 10−5 | 1.31 (1.15, 1.49) | 4.50 × 10−5 |
