Table 4 Sensitivity analyses for associations between antibiotic use and colorectal cancer.

From: Oral antibiotic use and early-onset colorectal cancer: findings from a case-control study using a national clinical database

 

2-year lag

Adjusted for comorbidities, smoking and alcohol (whole cases)

Adjusted for comorbidities, smoking and alcohol (MI)

Redefine age strata

Redefine age strata

  

<50 years

≥50 years

<50 years

≥50 years

<50 years

<50 years

<45 years

≥45 years

<55 years

≥55 years

Site

Cumulative exposure

Adjusteda OR (95% CI)

Adjusteda OR (95% CI)

Adjusteda OR (95%CI)

Adjusteda OR (95% CI)

Adjusteda OR (95% CI)

Adjusteda OR (95% CI)

Adjusteda OR (95% CI)

Adjusteda OR (95%CI)

Adjusteda OR (95% CI)

Adjusteda OR (95% CI)

Colon

0 days

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

 

≥1 day

1.42 (1.01, 1.99)

1.04 (0.96, 1.13)

1.46 (0.92, 2.34)

1.00 (0.90, 1.11)

1.50 (1.07, 2.09)

1.08 (1.00, 1.17)

1.79 (1.13, 2.84)

1.10 (1.02, 1.18)

1.22 (0.94, 1.58)

1.10 (1.01, 1.19)

 

1–15 days

1.52 (1.05,2.19)

1.05 (0.96, 1.14)

1.52 (0.93, 2.49)

1.00 (0.89, 1.12)

1.56 (1.09, 2.23)

1.08 (1.00, 1.18)

1.85 (1.14, 3.01)

1.10 (1.01, 1.20)

1.21 (0.91, 1.61)

1.11 (1.01, 1.21)

 

16–60 days

1.23 (0.74, 2.03)

1.03 (0.92, 1.15)

1.46 (0.76, 2.79)

1.00 (0.87, 1.14)

1.45 (0.90, 2.34)

1.07 (0.96, 1.19)

1.72 (0.90, 3.29)

1.08 (0.98, 1.20)

1.22 (0.85, 1.77)

1.09 (0.98, 1.22)

 

>60 days

1.13 (0.49, 2.59)

1.06 (0.88, 1.28)

0.78 (0.23, 2.57)

0.99 (0.80, 1.22)

1.01 (0.46, 2.24)

1.10 (0.93, 1.31)

1.35 (0.46, 4.02)

1.11 (0.94, 1.31)

1.25 (0.70, 2.22)

1.07 (0.90, 1.28)

 

P-trend

0.285

0.429

0.447

0.949

0.176

0.115

0.098

0.064

0.201

0.980

Rectum

0 days

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

1.00

 

≥1 day

1.08 (0.68, 1.71)

1.06 (0.95, 1.19)

0.87 (0.44, 1.69)

0.99 (0.85, 1.14)

1.16 (0.74, 1.83)

1.06 (0.95, 1.18)

0.94 (0.49, 1.79)

1.07 (0.96, 1.20)

1.29 (0.91, 1.83)

1.06 (0.95, 1.19)

 

1–15 days

0.94 (0.57, 1.56)

1.08 (0.95, 1.22)

0.71 (0.34, 1.50)

1.00 (0.85, 1.18)

0.97 (0.58, 1.62)

1.07 (0.95, 1.21)

0.64 (0.29, 1.41)

1.09 (0.97, 1.23)

1.36 (0.94, 1.97)

1·05 (0.93, 1.19)

 

16–60 days

1.38 (0.66, 2.91)

1.09 (0.92, 1.28)

1.56 (0.56, 4.38)

1.00 (0.83, 1.22)

1.89 (0.98, 3.65)

1.08 (0.93, 1.26)

1.97 (0.78, 4.95)

1.09 (0.94, 1.27)

1.21 (0.71, 2.06)

1.12 (0.96, 1.31)

 

>60 days

1.17 (0.40, 3.40)

0.91 (0.68, 1.22)

1.06 (0.28, 3.96)

0.79 (0.56, 1.12)

1.15 (0.45, 2.92)

0.89 (0.68, 1.16)

0.99 (0.25, 3.89)

0.89 (0.68, 1.16)

0.97 (0.45, 2.09)

0.92 (0.70, 1.22)

 

P-trend

0.593

0.577

0.830

.490

0.257

0.772

0.588

0.636

0.554

0.479

  1. OR odds ratio, CI confidence interval, MI multiple imputation.
  2. aAdjusted for diabetes, myocardial infarction, coronary heart disease, heart failure, peripheral vascular disease, dementia, cerebrovascular disease, chronic obstructive pulmonary disease, osteoporosis, renal disease, liver disease, hemiplegia/paraplegia, gallstones, acromegaly, low dose aspirin and NSAIDs.
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