Table 2 Gene ontology analysis in IR, IR with PEM, PTX, CDDP, DOC, CBDCA, and ETP groups.
From: Comprehensive screening for drugs that modify radiation-induced immune responses
IR | Â | Â | Â | Â | Â | Â | Â | Â |
Description | Gene ratio | q-value | Â | Â | Â | Â | Â | Â |
Type I interferon signalling pathway | 22/141 | 2.06E−23 |  |  |  |  |  |  |
Cellular response to type I interferon | 22/141 | 2.06E−23 |  |  |  |  |  |  |
Response to type I interferon | 22/141 | 4.012E−23 |  |  |  |  |  |  |
Response to virus | 26/141 | 1.383E−15 |  |  |  |  |  |  |
Interferon-gamma-mediated signalling pathway | 13/141 | 2.653E−10 |  |  |  |  |  |  |
Defence response to virus | 18/141 | 4.548E−10 |  |  |  |  |  |  |
Response to interferon-gamma | 16/141 | 4.747E−10 |  |  |  |  |  |  |
Cellular response to interferon-gamma | 15/141 | 8.889E−10 |  |  |  |  |  |  |
Defence response to other organisms | 23/141 | 3.836E−09 |  |  |  |  |  |  |
Regulation of viral life cycle | 12/141 | 5.747E−07 |  |  |  |  |  |  |
IR_PEM | Â | Â | IR_PTX | Â | Â | IR_CDDP | Â | Â |
Description | Gene ratio | q-value | Description | Gene ratio | q-value | Description | Gene ratio | q-value |
Type I interferon signalling pathway | 13/115 | 4.818E−11 | Response to virus | 13/82 | 1.031E−05 | Type I interferon signalling pathway | 17/87 | 2.2376E−19 |
Cellular response to type I interferon | 13/115 | 4.818E−11 | Regulation of viral genome replication | 8/82 | 1.658E−05 | Cellular response to type I interferon | 17/87 | 2.2376E−19 |
Response to type I interferon | 13/115 | 5.793E−11 | Viral genome replication | 8/82 | 7.319E−05 | Response to type I interferon | 17/87 | 3.3399E−19 |
Response to virus | 19/115 | 4.034E−10 | Negative regulation of viral genome replication | 6/82 | 0.000155 | Response to virus | 20/87 | 1.0874E−13 |
Regulation of viral genome replication | 9/115 | 6.746E−06 | Regulation of viral life cycle | 8/82 | 0.000185 | Regulation of viral genome replication | 10/87 | 2.0185E−08 |
Intrinsic apoptotic signalling pathway by p53 class mediator | 8/115 | 1.644E−05 | Cellular response to lipopolysaccharide | 8/82 | 0.0005666 | Regulation of viral life cycle | 11/87 | 6.2425E−08 |
Regulation of viral life cycle | 10/115 | 1.679E−05 | Regulation of inflammatory response | 11/82 | 0.0005666 | Defence response to virus | 13/87 | 6.2425E−08 |
Response to mineralocorticoid | 6/115 | 1.732E−05 | Cellular response to molecule of bacterial origin | 8/82 | 0.0005794 | Cellular response to interferon-gamma | 11/87 | 9.6465E−08 |
Mitotic cell cycle checkpoint | 10/115 | 1.817E−05 | Negative regulation of viral life cycle | 6/82 | 0.0005794 | Negative regulation of viral genome replication | 8/87 | 1.0189E−07 |
Regulation of viral process | 11/115 | 2.351E−05 | Viral life cycle | 10/82 | 0.0006948 | Response to interferon-gamma | 11/87 | 2.1916E−07 |
| Â | Â | Â | Type I interferon signalling pathway | 6/82 | 0.0006948 | Â | Â | Â |
IR_DOC | Â | Â | IR_CBDCA | Â | Â | IR_ETP | Â | Â |
Description | Gene ratio | q-value | Description | Gene ratio | q-value | Description | Gene ratio | q-value |
Response to virus | 16/77 | 2.362E−09 | Type I interferon signalling pathway | 20/135 | 1.463E−20 | Intrinsic apoptotic signalling pathway | 15/110 | 8.8923E−07 |
Type I interferon signalling pathway | 10/77 | 6.689E−09 | Cellular response to type I interferon | 20/135 | 1.463E−20 | Intrinsic apoptotic signalling pathway by p53 class mediator | 9/110 | 1.7839E−06 |
Cellular response to type I interferon | 10/77 | 6.689E−09 | Response to type I interferon | 20/135 | 2.547E−20 | Mitotic DNA damage checkpoint | 9/110 | 3.4334E−06 |
Response to type I interferon | 10/77 | 7.852E−09 | Response to virus | 22/135 | 8.958E−12 | Mitotic DNA integrity checkpoint | 9/110 | 3.4334E−06 |
Regulation of viral genome replication | 9/77 | 1.617E−07 | Response to interferon-gamma | 15/135 | 4.663E−09 | Mitotic G1 DNA damage checkpoint | 8/110 | 3.4334E−06 |
Viral genome replication | 9/77 | 1.166E−06 | Cellular response to interferon-gamma | 14/135 | 9.2E−09 | Mitotic G1/S transition checkpoint | 8/110 | 3.4334E−06 |
Regulation of viral life cycle | 9/77 | 5.169E−06 | Interferon-gamma-mediated signalling pathway | 11/135 | 4.93E−08 | G1 DNA damage checkpoint | 8/110 | 3.4334E−06 |
Regulation of viral process | 10/77 | 6.635E−06 | Negative regulation of viral genome replication | 9/135 | 2.127E−07 | Regulation of peptidase activity | 15/110 | 9.4432E−06 |
Regulation of symbiosis, encompassing mutualism through parasitism | 10/77 | 2.051E−05 | Regulation of viral genome replication | 10/135 | 1.088E−06 | Mitotic cell cycle checkpoint | 10/110 | 1.3216E−05 |
Negative regulation of viral genome replication | 6/77 | 3.328E−05 | Regulation of viral life cycle | 11/135 | 4.208E−06 | Intrinsic apoptotic signalling pathway in response to DNA damage by p53 class mediator | 6/110 | 6.9816E−05 |
| Â | Â | Â | Â | Â | Â | Type I interferon signalling pathway | 5/110 | 0.00564458 |
