Table 2 Over-optimism corrected diagnostic performance of single markers, by lag-time and ovarian cancer histology.
From: Prospective evaluation of 92 serum protein biomarkers for early detection of ovarian cancer
Lag-time (months) | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
0–18 | 0–9 | 9–18 | ||||||||||||||||
All | Serous | Non-serous | All | Serous | Non-serous | All | Serous | Non-serous | ||||||||||
Protein | AUC | 95% CI | AUC | 95% CI | AUC | 95% CI | AUC | 95% CI | AUC | 95% CI | AUC | 95% CI | AUC | 95% CI | AUC | 95% CI | AUC | 95% CI |
0.77 | 0.75–0.79 | 0.83 | 0.80–0.85 | 0.69 | 0.65–0.72 | 0.84 | 0.81–0.87 | 0.86 | 0.82–0.89 | 0.82 | 0.76–0.87 | 0.72 | 0.69–0.74 | 0.80 | 0.76–0.84 | 0.61 | 0.55–0.65 | |
0.73 | 0.71–0.74 | 0.78 | 0.75–0.80 | 0.66 | 0.63–0.68 | 0.86 | 0.82–0.89 | 0.88 | 0.83–0.91 | 0.82 | 0.75–0.87 | 0.63 | 0.61–0.66 | 0.70 | 0.65–0.74 | 0.56 | 0.51–0.59 | |
0.66 | 0.64–0.69 | 0.71 | 0.68–0.74 | 0.60 | 0.56–0.64 | 0.73 | 0.69–0.77 | 0.79 | 0.75–0.84 | 0.61 | 0.54–0.68 | 0.62 | 0.59–0.64 | 0.64 | 0.60–0.68 | 0.60 | 0.54–0.64 | |
0.61 | 0.59–0.63 | 0.66 | 0.63–0.69 | 0.54 | 0.50–0.57 | 0.73 | 0.69–0.77 | 0.78 | 0.73–0.83 | 0.65 | 0.57–0.71 | 0.52 | 0.49–0.56 | 0.57 | 0.52–0.62 | 0.53 | 0.48–0.59 | |
0.61 | 0.59–0.63 | 0.65 | 0.62–0.69 | 0.55 | 0.51–0.58 | 0.67 | 0.63–0.72 | 0.71 | 0.65–0.78 | 0.60 | 0.54–0.66 | 0.56 | 0.53–0.59 | 0.60 | 0.55–0.65 | 0.51 | 0.47–0.55 | |
WISP1 [8] | 0.61 | 0.59–0.63 | 0.62 | 0.59–0.65 | 0.59 | 0.54–0.63 | 0.73 | 0.68–0.76 | 0.72 | 0.66–0.77 | 0.74 | 0.67–0.80 | 0.52 | 0.49–0.55 | 0.54 | 0.50–0.59 | 0.51 | 0.47–0.56 |
0.59 | 0.58–0.61 | 0.54 | 0.49–0.57 | 0.68 | 0.63–0.71 | 0.63 | 0.59–0.66 | 0.58 | 0.52–0.62 | 0.71 | 0.65–0.77 | 0.57 | 0.55–0.59 | 0.50 | 0.46–0.57 | 0.65 | 0.59–0.70 | |
MSLN [10] | 0.59 | 0.57–0.60 | 0.60 | 0.57–0.63 | 0.57 | 0.54–0.60 | 0.67 | 0.64–0.69 | 0.74 | 0.70–0.77 | 0.55 | 0.48–0.61 | 0.53 | 0.48–0.55 | 0.52 | 0.48–0.56 | 0.58 | 0.54–0.61 |
ADAM8 | 0.56 | 0.53–0.58 | 0.58 | 0.54–0.61 | 0.53 | 0.49–0.57 | 0.68 | 0.63–0.71 | 0.75 | 0.67–0.80 | 0.56 | 0.49–0.62 | 0.53 | 0.50–0.56 | 0.56 | 0.52–0.61 | 0.51 | 0.47–0.56 |
