Table 1 Characteristics of participants with different glycemic status.

From: Cancer and its predictors in Chinese adults with newly diagnosed diabetes and impaired glucose tolerance (IGT): a 30-year follow-up of the Da Qing IGT and Diabetes Study

 

NGT

(n = 514)

IGT

(n = 575)

NDM

(n = 611)

P value

At baseline

    

  Age (years)

44.0 ± 8.9

45.2 ± 9.3

48.3 ± 8.8

<0.0001

  Sex (Male, %)

54.3

54.2

47.6

0.03

  Smoker (%)

44.5

41.3

34.4

0.002

  Obesity (%)

31.5

60.6

54.4

<0.0001

  Fasting glucose (mmol/L)

4.8 ± 0.7

5.6 ± 0.8

8.6 ± 3.1

<0.0001

  Glucose at 1 h (mmol/L)

6.7 ± 1.4

11.3 ± 2.0

16.0 ± 3.5

<0.0001

  Glucose at 2 h (mmol/L)

5.0 ± 1.2

9.0 ± 0.9

15.3 ± 3.6

<0.0001

  SBP (mmHg)

122 ± 21

133 ± 24

136 ± 24

<0.0001

  DBP (mmHg)

82 ± 14

88 ± 14

88 ± 14

<0.0001

  BMI (kg/M2)

23.7 ± 3.5

25.8 ± 3.8

25.5 ± 3.6

<0.0001

  Fasting insulin (mu/L)

18.1 ± 14.5

24.5 ± 16.1

–

<0.0001

  Insulin at 2 h (mu/L)

97.4 ± 57.5

123.9 ± 72.7

–

<0.0001

  Insulin at 2 h-Fasting insulin (mu/L)

63.7 ± 51.2

125.5 ± 75.5

–

<0.0001

  Insulin AUC (mu/L)a

136.8 ± 71.9

198.1 ± 103.3

–

<0.0001

Over 30 years of follow-up

    

  Cancer(n)

77

93

89

 

  Incidence of cancer per1000 person-years (95% CI)

6.06

6.77

7.18

0.02

  Cancer(n)

(4.9–7.5)

(5.6–8.2)

(5.8–8.9)

 

  Cancer-free time (years)

26.2 ± 8.1

23.7 ± 9.1

19.2 ± 6.9

<0.0001

  1. Data in the table are mean ± SD, unless otherwise indicated.
  2. BMI body mass index, CI confidence interval, DBP diastolic blood pressure, IGT impaired glucose tolerance, NDM newly diagnosed diabetes, NGT normal glucose tolerance, SBP systolic blood pressure, Cancer-free time years from entry to the diagnosis of cancer.
  3. aInsulin AUC, insulin area under the curve of 75 g glucose tolerance test was carried out in 507 participants including 200 cases in the NGT group and 307 cases in the IGT group.
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