Fig. 1: Opportunities and challenges of ctDNA in cancer.
The advantages and disadvantages of utilising ctDNA technology compared with tissue biopsy are highlighted in green and red boxes, respectively. The graph demonstrates varying ctDNA kinetics. Dotted blue lines demonstrate potential cases of early ctDNA clearance. ctDNA+: ctDNA positive result, ctDNA−: ctDNA negative result. 1Genomic changes refer to point mutations, gene re-arrangements, insertions/deletions, or copy number changes. Figure created with BioRender.com. TAT turn around time, TMB tumour mutational burden, TIL tumour-infiltrating lymphocytes, TCR T-cell receptor, CHIP Clonal hematopoiesis of indeterminate potential, CTC circulating tumour cell, TEP tumour-educated platelet, MRD minimal residual disease.
