Fig. 1: Bar chart indicating total variant counts in 36 childhood cancer genomes, and the clinical insight informed by these data. | British Journal of Cancer

Fig. 1: Bar chart indicating total variant counts in 36 childhood cancer genomes, and the clinical insight informed by these data.

From: The NHS England 100,000 Genomes Project: feasibility and utility of centralised genome sequencing for children with cancer

Fig. 1: Bar chart indicating total variant counts in 36 childhood cancer genomes, and the clinical insight informed by these data.The alt text for this image may have been generated using AI.

The panels beneath the bar chart indicate the clinical insight to inform diagnosis (U: uninformative, C: consistent, R: refine, M: modify), prognosis (P: informative) and therapy (T: informative) in each case. The number of somatically acquired indels was greatly elevated in samples prepared using a PCR based (nano-prep) protocol (b) compared to sequencing libraries prepared without PCR (a). MB medulloblastoma, EP anaplastic ependymoma, PB pineoblastoma, LGG/HGG biphasic neuroepithelial tumour, PA pilocytic astrocytoma, PXA glioma with molecular features of pleomorphic xanthoastrocytoma, DLGNT diffuse leptomeningeal glioneuronal tumour, DNET dysembryoplastic neuroepithelial tumour, AB astroblastoma, ACC adrenocortical carcinoma, HB hepatoblastoma, NB neuroblastoma, G-NB ganglio-neuroblastoma, WT Wilms’ tumour, RCC renal cell carcinoma, RMS rhabdomyosarcoma, US undifferentiated sarcoma, ES Ewing’s sarcoma, OS osteosarcoma, CIFS congenital infantile fibrosarcoma, IT immature teratoma, OV_GRAN ovarian granulosa cell tumour, LYM high-grade B cell lymphoma.

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