Table 2 Ratio between the observed annual colorectal cancer incidence rates per 100,000 persons aged 50–69 years in 2005–2016 and the rates that would be expected in the absence of the organised FIT screening programme, and annual and cumulative number of prevented colorectal cancer cases, by sex.

Year^a	Men			Women
Year^a	Incidence rate ratio [95% CI]	Annual number prevented	Cumulative number prevented	Incidence rate ratio [95% CI]	Annual number prevented	Cumulative number prevented
2005	1.11 [1.06, 1.16]	−91	−91	1.18 [1.13, 1.22]	−97	−97
2006	1.52 [1.46, 1.59]	−427	−518	1.45 [1.40, 1.51]	−249	−346
2007	1.20 [1.15, 1.25]	−163	−681	1.11 [1.07, 1.15]	−62	−408
2008	0.97 [0.93, 1.01]	21	−660	1.16 [1.12, 1.20]	−70	−478
2009	0.88 [0.85, 0.92]	77	−583	0.93 [0.89, 0.96]	32	−446
2010	0.78 [0.75, 0.81]	146	−437	0.94 [0.90, 0.97]	28	−418
2011	0.80 [0.76, 0.83]	137	−300	0.91 [0.88, 0.94]	41	−377
2012	0.73 [0.70, 0.76]	185	−115	0.80 [0.77, 0.83]	90	−287
2013	0.70 [0.67, 0.73]	204	89	0.77 [0.74, 0.80]	108	−179
2014	0.71 [0.68, 0.74]	179	268	0.74 [0.71, 0.77]	108	−71
2015	0.65 [0.62, 0.68]	220	488	0.84 [0.81, 0.87]	69	−2
2016	0.65 [0.62, 0.67]	229	717	0.81 [0.78, 0.84]	85	83

Emilia-Romagna Region, Italy, 2005–2016.
FIT faecal immunochemical test, CI (bootstrap-estimated) confidence interval.
^a2005 was the year of introduction of the screening programme. 2006 was the first full year of screening. The annual incidence rates that would be expected in 2005–2016 in the absence of screening were estimated by analysing the observed annual rates in 1997–2016 with an age-period-cohort model for men and an age-period model for women, i.e. the models providing the best fit to the observed rates. In both models, the values of parameters of the non-linear period effect were set to zero. All rates were age-standardised using the European standard population.

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