Fig. 1: BI 894999 and the detaching of BRD-NUT from chromatin.
From: Therapeutic impact of BET inhibitor BI 894999 treatment: backtranslation from the clinic
a Structure of the oral BET inhibitor BI 894999. b Immunofluorescence staining of NUT megadomains on the NC cell line Ty-82 treated with BET inhibitors for 30 min. BRD4-NUT detaches from chromatin with 10–30 nM BI 894999 (speckled staining changes to fuzzy staining).
