Fig. 1: Functional study of CTCs. | British Journal of Cancer

Fig. 1: Functional study of CTCs.

From: Functional analysis of circulating tumour cells: the KEY to understand the biology of the metastatic cascade

Fig. 1: Functional study of CTCs.The alternative text for this image may have been generated using AI.

The enrichment and subsequent expansion of CTCs have many translational applications. The analysis of these cells as CTC lines or xenografts can expand our comprehension of the metastatic process and lead to the identification of new biomarkers and/or pathways to propose potential new therapies against cancer. Moreover, an innovative functional approach, called EPIDROP, can help to study single viable CTCs directly from a blood sample. The analysis of viable CTCs might open the opportunity to test drugs in real time in vitro to evaluate therapy sensitivity/resistance: the oncogram.

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