Table 1 Demographic and clinicopathologic characteristics of colorectal cancer cases according to T cell proximity score.
From: Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer
T cell proximity score | |||||
|---|---|---|---|---|---|
Characteristic | Total N | Low | Intermediate | High | P |
All cases | 983 (100%) | 194 (20%) | 545 (55%) | 244 (25%) | |
Sex | 0.65 | ||||
Female | 481 (49%) | 96 (49%) | 260 (48%) | 125 (51%) | |
Male | 502 (51%) | 98 (51%) | 285 (52%) | 119 (49%) | |
Age (years) | 0.17 | ||||
<65 | 265 (27%) | 57 (29%) | 142 (26%) | 66 (27%) | |
65–75 | 348 (35%) | 58 (30%) | 211 (39%) | 79 (32%) | |
>75 | 370 (38%) | 79 (41%) | 192 (35%) | 99 (41%) | |
Year of operation | 0.26 | ||||
2000–2005 | 299 (30%) | 60 (31%) | 153 (28%) | 86 (35%) | |
2006–2010 | 315 (32%) | 65 (34%) | 183 (34%) | 67 (28%) | |
2011–2015 | 369 38%) | 69 (36%) | 209 (38%) | 91 (37%) | |
Tumour location | 0.0003 | ||||
Proximal colon | 478 (49%) | 82 (42%) | 249 (46%) | 147 (60%) | |
Distal colon | 359 (40%) | 83 (43%) | 214 (39%) | 62 (25%) | |
Rectum | 146 (15%) | 29 (15%) | 82 (15%) | 35 (14 %) | |
AJCC disease stage | <0.0001 | ||||
I | 162 (16%) | 19 (10%) | 84 (15%) | 59 (24%) | |
II | 371 (38%) | 62 (32%) | 193 (35%) | 116 (48%) | |
III | 322 (33%) | 80 (41%) | 186 (34%) | 56 (23%) | |
IV | 128 (13%) | 33 (17%) | 82 (15%) | 13 (5.3%) | |
Tumour grade | 0.061 | ||||
Low-grade (well to moderately differentiated) | 813 (83%) | 166 (86%) | 457 (84%) | 190 (78%) | |
High-grade (poorly differentiated) | 170 (17%) | 28 (14%) | 88 (16%) | 54 (22%) | |
Lymphovascular invasion | <0.0001 | ||||
No | 772 (79%) | 132 (68%) | 423 (78%) | 217 (89%) | |
Yes | 211 (21%) | 62 (32%) | 122 (22%) | 17 (11%) | |
MMR status | <0.0001 | ||||
MMR proficient | 833 (85%) | 184 (95%) | 485 (89%) | 164 (67%) | |
MMR deficient | 150 (15%) | 10 (5.2%) | 60 (11%) | 80 (33%) | |
BRAF status | <0.0001 | ||||
Wild-type | 824 (84%) | 177 (91%) | 469 (86%) | 178 (73%) | |
Mutant | 159 (16%) | 17 (8.8%) | 76 (14 %) | 66 (27%) | |
