Table 2 Univariable and multivariable Cox regression models for cancer-specific survival and overall survival according to T cell proximity score and T cell density score.

		Colorectal cancer-specific survival			Overall survival
	No. of cases	No. of events	Univariable HR (95% CI)	Multivariable HR (95% CI)	No. of events	Univariable HR (95% CI)	Multivariable HR (95% CI)
T cell proximity score
Low	194	88	1 (referent)	1 (referent)	127	1 (referent)	1 (referent)
Intermediate	545	157	0.57 (0.44–0.75)	0.72 (0.55–0.94	269	0.66 (0.53–0.81)	0.74 (0.59–0.91)
High	244	25	0.18 (0.12–0.29)	0.33 (0.20–0.52)	98	0.47 (0.36–0.61)	0.57 (0.43–0.76)
P_trend			<0.0001	<0.0001		<0.0001	0.0001
T cell density score
Low	163	64	1 (referent)	1 (referent)	98	1 (referent)	1 (referent)
Intermediate	596	172	0.69 (0.52–0.93)	0.74 (0.55–0.99)	302	0.78 (0.62–0.99)	0.78 (0.62–0.99)
High	224	34	0.34 (0.22–0.51)	0.47 (0.31–0.73)	94	0.59 (0.44–0.78)	0.62 (0.46–0.84)
P_trend			<0.0001	0.0007		0.0002	0.002

Multivariable Cox proportional hazards regression models were adjusted for sex, age (<65, 65–75, >75), year of operation (2000–2005, 2006–2010, 2011–2015), tumour location (proximal colon, distal colon, rectum), disease stage (I–II, III, IV), tumour grade (well/moderately differentiated, poorly differentiated), lymphovascular invasion (negative, positive), MMR status (proficient, deficient), BRAF status (wild-type, mutant).
P_trend values were calculated by using the three ordinal categories of T cell proximity score and T cell density score as continuous variables in univariable and multivariable Cox proportional hazard regression models.
CI confidence interval, HR hazard ratio.

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