Fig. 2: Immunohistochemical analysis reveals the characteristics of local immune milieu of highly immunogenic ICCs. | British Journal of Cancer

Fig. 2: Immunohistochemical analysis reveals the characteristics of local immune milieu of highly immunogenic ICCs.

From: Regulatory T cells induce a suppressive immune milieu and promote lymph node metastasis in intrahepatic cholangiocarcinoma

Fig. 2

a Upper images show representative CD8+ TIL counts in ICCs. Left side shows low counts of CD8+ TILs and right side high counts of infiltrating TILs. Lower bar graphs show the distribution of CD8+ TIL counts in intra-tumour and stroma of ICC. b Boxplot showing that CD8+ TIL counts are higher in the stroma than in the tumour. The upper and lower bars represent 5% and 95%, respectively. ***P < 0.001. c Upper images show representative FoxP3+ TIL counts in ICCs. Left side shows low counts of FoxP3+ TILs and right side high counts of infiltrating TILs. Lower bar graphs show the distribution of FoxP3+ TIL counts in intra-tumour and stroma of ICC. d Boxplot showing that FoxP3+ TIL counts are higher in the stroma than in the tumour. The upper and lower bars represent 5% and 95%, respectively. ***P < 0.001.

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