Fig. 4: cGAS/STING pathway-dependent cytokine expression in HeLa cells. | British Journal of Cancer

Fig. 4: cGAS/STING pathway-dependent cytokine expression in HeLa cells.

From: Topoisomerase I poison-triggered immune gene activation is markedly reduced in human small-cell lung cancers by impairment of the cGAS/STING pathway

Fig. 4

a Cytokines expression in HeLa cells transfected with scrambled siRNA (Sc) or two different siRNA against STING (#1 and #2). Asterisks indicate statistical significance of silenced sample compared to scramble by t test. *P < 0.05. b WB of STING protein level in not treated B16 WT and KO for STING cell line. c Cytokines expression was analysed as in panel a in both WT and KO for STING B16 cell. Asterisks indicate statistical significance in comparison with untreated cells by t test. *P < 0.05, **P < 0.01. d Expression level of cytokine genes in HeLa overexpressing RNaseH1 cell line in response to CPT and LMP776. Data are represented as mean of two biological replicates ± SEM; P values are indicated on the top of each bar and they are calculated as one-tailed ratio paired t test.

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