Fig. 6: STING gene expression is downregulated in SCLC and correlates with interferon response activation. | British Journal of Cancer

Fig. 6: STING gene expression is downregulated in SCLC and correlates with interferon response activation.

From: Topoisomerase I poison-triggered immune gene activation is markedly reduced in human small-cell lung cancers by impairment of the cGAS/STING pathway

Fig. 6

a Violin plot of STING gene expression across different lung cancer histopathology types. P value of the Wilcoxon test and the number of samples for each group are reported in the plot. b Violin plot of ssGSEA enrichment score of “GO: Response to Interferon Beta” gene set across different lung cancer histopathology types. P value of Wilcoxon test and the number of samples for each group are reported in the plot. c, d Violin plot of ssGSEA enrichment score of NF-kB-target and IRF-target gene sets, respectively, across different lung cancer histopathology types. P value of the Wilcoxon test and the number of samples for each group are reported in the plot. e Scatter plots of STING gene expression correlated to ssGSEA enrichment score of “GO: Response to Interferon Beta” gene set for each lung cancer type. Spearman correlation coefficient (R) and P value of correlation test are reported in each graph.

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