Fig. 3: Relationship between PD-1⁺CD8⁺ T cell infiltration and responsiveness of 5-fluorouracil-based adjuvant chemotherapy.

a Kaplan–Meier curves of OS in patients with TNM Stage II and III GC (n = 382, P < 0.001, HR = 0.49) (left panel), patients with high PD-1⁺CD8⁺ T cell infiltration (n = 172, P = 0.007, HR = 0.57) (middle panel) and patients with low PD-1⁺CD8⁺ T cells (n = 156, P < 0.001, HR = 0.33) (right panel) according to ACT application. Log-rank test was applied to Kaplan–Meier curves. b Kaplan–Meier curves of OS in patients with TNM Stage II GC (n = 101, P = 0.020, HR = 0.45) (left panel), patients with high PD-1⁺CD8⁺ T cell infiltration (n = 51, P = 0.019, HR = 0.36) (middle panel) and patients with high PD-1⁺CD8⁺ T cells (n = 50, P = 0.34, HR = 0.59) (right panel) according to ACT application. Log-rank test was applied to Kaplan–Meier curves. c Kaplan–Meier curves of OS in patients with TNM Stage III tumours (n = 227, P < 0.001, HR = 0.32) (left panel), patients with high PD-1⁺CD8⁺ T cell infiltration (n = 121, P < 0.001, HR = 0.36) (middle panel) and patients with high PD-1⁺CD8⁺ T cells (n = 106, P < 0.001, HR = 0.21) (right panel) according to ACT application. Log-rank test was applied to Kaplan–Meier curves.