Fig. 8: Our model for the excess risk of malignancy associated with irradiation, from Eq. (44). | British Journal of Cancer

Fig. 8: Our model for the excess risk of malignancy associated with irradiation, from Eq. (44).

From: A mechanistic mathematical model of initiation and malignant transformation in sporadic vestibular schwannoma

Fig. 8

This model is based on the frequency of DSB induction by irradiation, and accounts for both tumour volume and cell survival (see the section “Modelling excess risk of malignancy following irradiation”) [8, 64, 65]. The dose is assumed to be delivered in a single fraction, as in stereotactic radiosurgery. Fractionated radiotherapy should have a similar dose–response relationship if scheduled properly (see the section “Dose fractionation”). a The excess risk of a radiation-induced DSB deactivating a tumour suppressor as a function of both tumour diameter (y axis) and dose (x axis), for nTSX = 1245 (best estimate from section “Parameter estimation”) and mTSX = 0.42 × 1245 = 523 (from Eq. (37)). b The risk of deactivating a tumour suppressor in a tumour of diameter 20 mm as a function of dose: for example values of nTSX of 100 (lower curve, dotted), 1245 (middle curve, solid), and 104 (upper curve, dashed), and values of mTSX = 0.42nTSX.

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