Fig. 1: Elevated TIS signature and IFN signalling in breast cancer patients (TCGA-BRCA) carrying mtp53.

a Expression of a majority of TIS signature genes was significantly upregulated in breast cancer patients carrying mtp53. Bar graphs were generated by graphpad prism: the expression of z-score of each gene in the TIS signature genes in either mtp53 or wtp53 TCGA-BRCA. Error bars represent the standard deviation of expression of a gene across breast cancer patient samples. b Interferons (IFNs), interferon-sensitive genes (ISGs) and antigen processing and presentation genes were upregulated in breast cancer patients carrying mt p53, as shown in the box and whiskers plot (whiskers from min to max, shown are all data points). a, b Patient samples carrying p53 missense mutation or in frame deletion/insertion were grouped into p53 mutant. There were 618 patients carrying wtp53 and 258 patients carrying mtp53. p value is two-tailed and centre values are median. Mann–Whitney test. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001.