Fig. 2: Mtp53-dependent elevated IFN signalling and ERVs expression in cancer cell lines.
From: Mutant p53 gain of function mediates cancer immune escape that is counteracted by APR-246
a Downregulation of type I and/or type III IFNs, and ERVs after knockdown of mtp53 in p53 mutant cancer cell lines, as assessed by qPCR (n = 3). Human breast cancer cell lines: BT-549, MDAMB-468 and MDAMB-231; human bladder cancer cell line, J82 and mouse fibrosarcoma MCO4. b Knockdown of mtp53 did not affect expression of IFNs and ERVs in another set of p53 mutant cancer cell lines, as assessed by qPCR (n = 3). Human colorectal cancer cell lines: DLD-1 and SW-480; human breast cancer cell lines: BT-20 and SKBR-3. a, b Each condition contains three biological repeats and each biological repeat includes three technical repeats. Unpaired student t-test, Centre values are mean, Error bars, s.d. p value is two-tailed. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001.
