Table 2 Association of stratified FOXJ1 expression and OS by histotype (n = 6434).

From: Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study

Histotype

Expression

na

5-year survival (% ± SE)

HR (95% CI)b

p value

HGSC

0%

1336

36.0 ± 1.4

Ref.

0.0002*

 

5%

987

34.1 ± 1.6

1.03 (0.94–1.14)

 
 

10–15%

916

40.6 ± 1.7

0.92 (0.83–1.02)

 
 

20–45%

1062

43.0 ± 1.6

0.86 (0.77–0.95)*

 
 

50–100%

358

48.0 ± 2.8

0.78 (0.67–0.91)*

 

LGSC

0%

32

48.8 ± 10.36

Ref.

0.3229

 

5%

24

45.9 ± 10.9

1.45 (0.63–3.35)

 
 

10–15%

37

59.4 ± 8.7

0.81 (0.39–1.69)

 
 

20–45%

50

67.7 ± 7.3

1.08 (0.53–2.21)

 
 

50–100%

35

66.5 ± 9.1

0.65 (0.30–1.40)

 

MC

0%

216

66.5 ± 3.6

Ref.

0.2185

 

5%

15

69.4 ± 12.7

9.78 (0.35–2.76)

 
 

10–15%

7

69.4 ± 17.9

2.24 (0.63–7.99)

 
 

20–45%

13

53.3 ± 15.1

1.15 (0.50–2.67)

 
 

50–100%

5

100.0 ± 0.0

N/A

 

EC

0%

221

76.4 ± 3.1

Ref.

0.707

 

5%

110

76.7 ± 4.7

0.81 (0.50–1.33)

 
 

10–15%

128

83.7 ± 3.8

0.76 (0.47–1.24)

 
 

20–45%

187

83.8 ± 2.9

0.78 (0.51–1.19)

 
 

50–100%

100

81.7 ± 4.0

0.94 (0.58–1.53)

 

CCC

0%

174

52.9 ± 4.1

Ref.

0.03*

 

5%

67

63.2 ± 6.5

0.69 (0.44–1.09)

 
 

10–15%

69

72.3 ± 6.1

0.50 (0.30–0.83)*

 
 

20–45%

147

57.0 ± 4.3

0.84 (0.60–1.18)

 
 

50–100%

163

69.7 ± 3.7

0.64 (0.44–0.93)*

 
  1. CCC clear cell ovarian carcinoma, CI confidence interval, EC endometroid ovarian carcinoma, HGSC high-grade serous ovarian carcinoma, HR hazard ratio, LGSC low-grade serous ovarian carcinoma, MC mucinous ovarian carcinoma, OS overall survival.
  2. aThe same cohort was assessed in univariate survival analysis.
  3. bHR adjusted for patient age and stage and stratified by OTTA study; Cox proportional regression modelling was used to calculate p values and define significance. Statistically significant values are shown in bold; *p < 0.05.
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