Table 2 Hazard ratios (HRs) and 95% confidence intervals (CIs) for pancreatic cancer according to dental health status at first visits, stratified by age at entry.

From: Poor dental health and risk of pancreatic cancer: a nationwide registry-based cohort study in Sweden, 2009–2016

Groups

Person-years (*100,000)

Cancer cases (%)

Crude modela, HR (95% CI)

Multivariable-adjusted modelb, HR (95% CI)

>19 and <50 years

 Total

197.1

464 (100)

  

   Healthy

104.3

190 (40.9)

Ref.

Ref.

   Caries

35.5

78 (16.8)

1.09 (0.82–1.45)

1.13 (0.87–1.47)

   Root canal infection

8.3

35 (7.5)

1.74 (1.14–2.64)*

1.58 (1.10–2.28)*

   Mild inflammation

36.3

98 (21.1)

1.37 (1.06–1.77)*

1.35 (1.06–1.72)*

   Periodontitis

12.7

63 (13.6)

1.68 (1.24–2.28)***

1.56 (1.17–2.08)**

P for trendc

  

<0.001

<0.001

≥50 and <70 years

 Total

128.9

4724 (100)

  

   Healthy

56.2

1942 (41.1)

Ref.

Ref.

   Caries

19.1

654 (13.8)

1.00 (0.91–1.09)

0.98 (0.90–1.08)

   Root canal infection

6.1

226 (4.8)

1.12 (0.97–1.28)

1.05 (0.92–1.21)

   Mild inflammation

24.2

808 (17.1)

0.96 (0.88–1.43)

0.98 (0.90–1.06)

   Periodontitis

23.3

1094 (23.2)

1.25 (1.16–1.35)***

1.20 (1.11–1.29)***

P for trendc

  

<0.001

<0.001

≥70 years

 Total

48.2

4893 (100)

  

   Healthy

21.6

2229 (45.6)

Ref.

Ref.

   Caries

7.4

727 (14.9)

0.95 (0.87–1.03)

0.95 (0.87–1.03)

   Root canal infection

1.8

179 (3.7)

0.98 (0.84–1.14)

0.98 (0.84–1.14)

   Mild inflammation

8.5

838 (17.1)

0.96 (0.89–1.04)

0.97 (0.90–1.05)

   Periodontitis

8.9

920 (18.8)

1.02 (0.94–1.10)

1.01 (0.94–1.10)

P for trendc

  

0.965

0.882

  1. *P < 0.05; **P < 0.01; ***P < 0.001.
  2. aTime scale is attained age, crude model.
  3. bTime scale is attained age, with adjustment for sex, calendar year, family income, education, family history of pancreatic cancer, smoking-related diseases, alcohol-related disorders and diseases, and number of teeth.
  4. cCochran–Armitage test was used to test for trend.
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