Fig. 1: Summary of current clinical and biochemical knowledge on human UGT2B17 and UGT2B28.
From: Extensive metabolic consequences of human glycosyltransferase gene knockouts in prostate cancer
Frequencies of UGT complete gene deletions (KO) vary among ethnic groups. (a) UGT2B17 homozygous gene deletion: Caucasians: 9%; Africans: 4%; Asians: 70% [7]. (b) UGT2B28 homozygous gene deletion: Caucasians: 3%; Africans: 10%; Asians: 2% (based on the frequency of the tag SNP rs12507041 GG genotype reported in the 1000 Genome project Phase 3 (https://m.ensembl.org/Homo_sapiens/Variation/Population?db=core;r=4:69395647-69396647;v=rs12507041;vdb=variation;vf=96007771; searched May 31, 2021). References to relevant literature are provided in the text. FA fatty acids, G UGT-derived glucuronide products, GI gastrointestinal. 1Complete tissue expression profile is provided in Supplementary Fig. S1.
