Fig. 2: Summary of circulating metabolites changed in KO vs gene-proficient controls.
From: Extensive metabolic consequences of human glycosyltransferase gene knockouts in prostate cancer
a Experimental design. b Number of changed metabolites in KO cases (higher than controls: red; lower than controls: blue; P ≤ 0.05). c Main global metabolic pathways perturbed in KO cases. Superpathways and Enrichment scores are according to Metabolon, as described in 'Methods'. d, e Volcano plots of d global and e lipidomics data. % metabolites higher or lower than control individuals are given (detailed in Supplementary Table S1). The statistical significance of fold change (FC) was determined by paired test on log-transformed data. DAG diacylglycerol, DHA docosahexanoic acid, FA fatty acids, KO knock out, MAG monoacylglycerol, TAG triacylglycerol.
