Table 1 Clinical and pathological characteristics of matched samples in UGT groups.

From: Extensive metabolic consequences of human glycosyltransferase gene knockouts in prostate cancer

Characteristics

Controlsa

UGT2B17 KOb

UGT2B28 KOc

 

n = 30

n = 30

n = 24

Mean age at diagnosis ± SD (years)

61.7 ± 5.6

64.0 ± 4.9

62.6 ± 5.6

 Range

51.7–70.7

53.8–73.4

53.7–73.7

PSA at diagnosis ± SD (ng/ml)

7.4 ± 7.5

7.0 ± 5.0

7.6 ± 4.7

 Range

2.3–45.4

1.2–21.0

3.9–24.2

 

n (%)

n (%)

n (%)

Pathologic Gleason score

   

 <7

6 (20%)

7 (23%)

5 (21%)

 7

23 (77%)

22 (74%)

18 (75%)

 >7

1 (3%)

1 (3%)

1 (4%)

Pathologic T stage

   

 <pT3a

15 (50%)

18 (60%)

13 (54%)

 pT3a

13 (43%)

10 (33%)

9 (38%)

 >pT3a

2 (7%)

2 (7%)

2 (8%)

  1. aSubjects carrying both copies of the UGT2B17 and UGT2B28 genes.
  2. bSubjects homozygous for UGT2B17 gene deletion (KO) and carrying both copies of the UGT2B28 gene
  3. cSubjects carrying both copies of the UGT2B17 gene and homozygous for UGT2B28 gene deletion (KO).
  4. PSA: prostate serum antigen at diagnosis; age at PCa diagnosis.
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