Fig. 1: Concordant MMR protein expression between paired curettage and hysterectomy samples (n = 424). | British Journal of Cancer

Fig. 1: Concordant MMR protein expression between paired curettage and hysterectomy samples (n = 424).

From: Mismatch repair markers in preoperative and operative endometrial cancer samples; expression concordance and prognostic value

Fig. 1

Mismatch repair (MMR) deficiency was defined as loss of one or more MMR proteins as indicated above images. Differential expression levels were defined by staining index (SI) 0–9 (0, 1, 2, 3, 4, 6 and 9), as indicated below images (a). A moderate agreement in MSH6 expression and a substantial agreement in MSH2, PMS2 and MLH1 expression was found between pairs of curettage- and hysterectomy samples (b). Paired samples showed substantial concordance in MMR status (MMR-D versus MMR-P) (c). κ Cohen’s kappa coefficient, MSH6 MutS Homolog 6, MSH2 MutS Homolog 2, PMS2 PMS2 Homolog 2, MLH1 MutL Homolog 1, MMR-D mismatch repair deficient, MMR-P mismatch repair proficient. *Mean prevalence of MSH6 and MSH2 loss is <10% implying that κ values are conservative estimates. N = Shared intact expression/shared loss of expression/discordant: intact curettage, loss hysterectomy/discordant: loss curettage, intact hysterectomy.

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