Fig. 3: miR-105-5p associates with reduced OS.

a Kaplan–Meier OS curves for miR-105-5p in the discovery cohort. The “+” sign on the curves indicates censored patients. The number of patients at risk at each interval is shown. At diagnosis, 36 patients had a high miR-105-5p expression, and 50 patients had low miR-105-5p expression. The P value is calculated by the log-rank test in the coxph-function in R. Hazard ratio and confidence interval are calculated by the coxph-function in R. b Kaplan–Meier PFS survival curves for miR-105-5p in the discovery cohort. At diagnosis, 35 patients had high miR-105-5p expression, and 47 patients had low miR-105-5p expression. Statistics calculated as described in a). c Forest plots for the univariate cox regression analyses of clinical parameters with respect to OS. Shown are parameters that were detected as significant, in addition to age which was not detected as significant. Statistics calculated as described in a). d Multivariate cox regression analysis of miR-105-5p with respect to OS adjusted for age, sex, ISS stage, haemoglobin, creatine, calcium, albumin and beta-2 microglobulin (B2M). Statistics calculated as described in a). e Kaplan–Meier OS curve for miR-105-5p in the validation cohort of the Kruykov et al. [32] Statistics calculated as described in a).