Table 5 Univariate and multivariate recurrence risk analysis in stage I–III colon cancers (N = 554).
From: The Glasgow Microenvironment Score and risk and site of recurrence in TNM I–III colorectal cancer
Clinicopathological characteristics | Local recurrences only | Local + systemic | Distant only | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Univariate HR (95% CI) | p | Multivariate HR (95% CI) | p | Univariate HR (95% CI) | p | Multivariate HR (95% CI)a | p | Univariate HR (95% CI) | p | Multivariate HR (95% CI) | p | |
Age | ||||||||||||
≤64 | ||||||||||||
65–74 | ||||||||||||
≥75 | 1.42 (0.89–2.25) | 0.14 | – | – | 1.00 (0.57–1.78) | 0.99 | – | – | 1.16 (0.90–1.50) | 0.26 | – | – |
Gender | ||||||||||||
Female | ||||||||||||
Male | 0.81 (0.39–1.67) | 0.56 | – | – | 0.68 (0.27–1.73) | 0.42 | – | – | 1.10 (0.72–1.66) | 0.67 | – | – |
Presentation | ||||||||||||
Elective | ||||||||||||
Emergency | 1.20 (0.36–3.95) | 0.77 | – | – | 2.93 (0.96–8.91) | 0.06 | – | – | 2.10 (1.22–3.61) | 0.007 | – | 0.19 |
TNM | ||||||||||||
I | ||||||||||||
II (low risk) | ||||||||||||
III (high risk) | 2.14 (1.16–3.92) | 0.01b | – | – | 3.11 (1.33–7.24) | 0.009b | – | – | 1.90 (1.35–2.66) | <0.001b | – | – |
T-stage | ||||||||||||
T1 | ||||||||||||
T2 | ||||||||||||
T3 | ||||||||||||
T4 | 1.86 (1.06–3.26) | 0.03 | – | 0.10 | 5.95 (2.24–15.82) | <0.001 | – | – | 1.71 (1.25–2.34) | <0.001 | – | 0.08 |
N-stage | ||||||||||||
N0 | ||||||||||||
N1 | ||||||||||||
N2 | 1.92 (1.20–3.09) | 0.007 | 1.71 (1.04–2.79) | 0.03 | 2.28 (1.39–4.42) | 0.002 | – | – | 1.61 (1.22–2.13) | <0.001 | 1.40 (1.05–1.89) | 0.02 |
Differentiation | ||||||||||||
Well/mod | ||||||||||||
Poor | 1.93 (0.73–5.05) | 0.18 | – | – | 1.15 (0.27–5.01) | 0.85 | – | – | 1.14 (0.59–2.19) | 0.70 | – | – |
MMR status | ||||||||||||
Proficient | ||||||||||||
Deficient | 1.54 (0.61–3.89) | 0.36 | – | – | 0.92 (0.27–3.17) | 0.89 | – | – | 1.07 (0.62–1.85) | 0.80 | – | – |
Venous invasion | ||||||||||||
Absent | ||||||||||||
Present | 0.82 (0.40–1.71) | 0.61 | – | – | 3.48 (1.15–10.58) | 0.03 | – | – | 2.04 (1.32–3.16) | 0.001 | 1.65 (1.04–2.60) | 0.03 |
mGPS | ||||||||||||
0 | ||||||||||||
1 | ||||||||||||
2 | 1.17 (0.73–1.89) | 0.52 | – | – | 1.81 (1.05–3.15) | 0.03 | – | – | 1.39 (1.08–1.80) | 0.01 | 1.32 (1.01–1.72) | 0.04 |
GMS | ||||||||||||
0 | ||||||||||||
1 | – | – | ||||||||||
2 | 1.66 (0.89–3.08) | 0.11 | – | – | 2.08 (0.94–4.57) | 0.07 | 1.55 (1.09–2.19) | 0.02 | – | 0.25 | ||
