Fig. 2: Regulatory crosstalk of PD-L2 in cancer.
From: Evolving landscape of PD-L2: bring new light to checkpoint immunotherapy
The role of programmed death ligand-2 (PD-L2) in the maintenance of the tumour microenvironment (TME) and the potential mechanisms of PD-L2 that may contribute to tumour development is shown. PD-L2 is a key factor in tumour progression and immune responses. PD-L2 expression can not only be regulated by the pathway network in a single cell but can also be modulated by cell factors in the TME that form a complex network between different cells.
