Fig. 3: Difference in chromatin accessibility between ER + /HER2− tumours and TNBC. | British Journal of Cancer

Fig. 3: Difference in chromatin accessibility between ER + /HER2− tumours and TNBC.

From: Chromatin profile-based identification of a novel ER-positive breast cancer subgroup with reduced ER-responsive element accessibility

Fig. 3

a Flow chart of peak filtering. The number of cancer CREs (n = 133,333) was identified by subtracting the number of TME-specific peaks (n = 12,796) from the total number of distal elements (n = 146,129). b Volcano plot showing the differential accessibility analysis of CREs between ER + /HER2− and TNBC. Significantly different CREs are coloured red (TNBC-specific) or blue (ER + /HER2 − -specific). c, d Bar plots of GO enrichment obtained via GREAT analysis of ER + /HER2 − -specific peaks (c) and TNBC-specific peaks (d). e, f Bar plots of the motif enrichment significance (P-value) of Homer known motifs for ER + /HER2 − -specific peaks (e) and TNBC-specific peaks (f). Known motif sequences are shown on the right.

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