Fig. 4: Chromatin accessibility-based classification of ER + /HER2 − tumours and the cis-regulatory landscape. | British Journal of Cancer

Fig. 4: Chromatin accessibility-based classification of ER + /HER2 − tumours and the cis-regulatory landscape.

From: Chromatin profile-based identification of a novel ER-positive breast cancer subgroup with reduced ER-responsive element accessibility

Fig. 4

a Flow chart of tumour classification. Across 35 ER + /HER2 − tumours, the top 50,000 variable CREs were selected from 133,333 distal cancer CREs, after which hierarchical clustering was performed. b Heatmap showing the chromatin accessibility of k-means clusters of the top 50,000 variable CREs (Modules 1–5). The annotation above the heatmap represents chromatin accessibility clusters and patient information. Boxes on the right represent the number of CREs and TF motif enrichment in each peak set.

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