Fig. 7: Chromatin accessibility-based classification of TCGA–BRCA ER + /HER2 − tumours. | British Journal of Cancer

Fig. 7: Chromatin accessibility-based classification of TCGA–BRCA ER + /HER2 − tumours.

From: Chromatin profile-based identification of a novel ER-positive breast cancer subgroup with reduced ER-responsive element accessibility

Fig. 7

a Flow chart of peak filtering and tumour classification. The distal cancer CREs (n = 150,039) were identified by removing TME-specific peaks (n = 10,381) from the distal elements (n = 160,420). Across 45 ER + /HER2 − tumours, the top 50,000 variable CREs were selected from 150,039 distal cancer CREs, after which hierarchical clustering was performed. b Heatmap showing the chromatin accessibility of the k-means clusters of the top 50,000 variable CREs (Modules 1–5). The annotation above the heatmap represents chromatin accessibility clusters, PAM50 classification and histological type. Boxes on the right represent the number of CREs and TF motif enrichment in each peak set.

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