Table 1 Patient demographics and disease characteristics.

From: Safety, tolerability, and pharmacokinetics of Aurora kinase B inhibitor AZD2811: a phase 1 dose-finding study in patients with advanced solid tumours

 

Total (N = 51)

Median age (range), years

61 (38–81)

Sex, n (%)

  Male

22 (43.1)

  Female

29 (56.9)

Race, n (%)

  White

45 (88.2)

  Black or African American

3 (5.9)

  Other

1 (2.0)

  Missing

2 (3.9)

ECOG PS, n (%)

  0

15 (29.4)

  1

35 (68.6)

  2

1 (2.0)a

Number of prior systemic therapies

  Median (range)

3 (1–9)

  1 line, n (%)

7 (13.7)

  2–3 lines, n (%)

25 (49.0)

  >3 lines, n (%)

19 (37.3)

Best overall response to most recent prior regimen, n (%)

  CR

1 (2.0)

  PR

6 (11.8)

  Non-CR/non-PD

2 (3.9)

  SD

16 (31.4)

  PD

18 (35.3)

  NE

1 (2.0)

  NA

6 (11.8)

  Missing

1 (2.0)

Primary diagnosis, n (%)

  Breast

10 (19.6)

  Colon

3 (5.9)

  Lung

15 (29.4)

  NSCLC

7 (13.7)

  SCLC

7 (13.7)

  Mesothelioma

1 (2.0)

  Ovary

2 (3.9)

  Prostate

6 (11.8)

  Other

15 (29.4)

  1. CR complete response, ECOG PS Eastern Cooperative Oncology Group performance status, NA not available, NE not evaluable, PD progressive disease, PR partial response, SD stable disease.
  2. aPatient enrolled in error.