Table 1 Baseline characteristics.

From: Randomised controlled trial of breast cancer and multiple disease prevention weight loss programmes vs written advice amongst women attending a breast cancer family history clinic

 

Written advice (n = 37)

BCPP (n = 86)

MDPP (n = 87)

Study centre n (%)

MFT

32 (87%)

75 (88%)

79 (91%)

T&GICFT

3 (8%)

9 (10%)

7 (8%)

UHS

2 (5%)

2 (2%)

1 (1%)

Age median (IQR)

49 (44–52)

48 (44–52)

48 (43–51)

Pre/postmenopausal n (%)

24/13 (65/35%)

55/31 (64/36%)

51/36 (58/42%)

Ethnicity n (%)

White

34 (92%)

82 (95%)

84 (96%)

Asian/Black

3 (8%)

4 (5%)

3 (4%)

BMI (kg/m2) median (IQR)

30.4 (28.3–32.8)

31.1 (28.4–36.1)

31.6 (27.8–36.2)

Overweight (BMI 25–29.99 kg/m2) n (%)

17 (46%)

37 (42%)

38 (44%)

Obese (BMI > 30 kg/m2) n (%)

20 (54%)

49 (58%)

49 (56%)

Smoking status n (%)

Current

3 (8%)

4 (5%)

5 (6%)

Previous

13 (35%)

29 (33%)

30 (34%)

Never

21 (57%)

53 (62%)

52 (60%)

Years since joining the FHRPC median (IQR)

5.5 (2.9–10.3)

4.1 (1.0–10.8)

5.7 (2.3–12.4)

Estimated % lifetime BC risk at baseline (T-C) mean (SD)

26 (9)

25 (10)

24 (12)

Moderate (≥17–29.99%)

26 (70%)

66 (77%)

68 (78%)

High (>30%)

11 (30%)

20 (23%)

19 (22%)

Change in breast cancer risk category between joining the FHRPC and the study

Increase

4 (11%)

7 (8%)

7 (8%)

Stable

26 (70%)

43 (50%)

46 (53%)

Decrease

7 (19%)

30 (34%)

28 (32%)

Not updated

0 (0%)

7 (8%)

5 (6%)

Gene variant status

Positive individual

1 (3%)

0 (0%)

3 (3%)

Positive family & individual untested

0 (0%)

1 (1%)

3 (3%)

Positive family & individual negative

0 (0%)

3 (3%)

2 (2%)

Prescribed BC risk reducing medication

Already taking at baseline

1 (3%)

5 (6%)

3 (3%)

Commenced at baseline

4 (11%)

10 (11%)

2 (2%)

Family history of CVDa

9 (24%)

22 (26%)

17 (20%)

Family history of T2Db

10 (27%)

18 (17%)

31 (36%)

IMD Quintile

1 (most deprived

6 (16%)

13 (15%)

20 (23%)

2

8 (21%)

12 (4%)

12 (14%)

3

8 (22%)

16 (18%)

23 (26%)

4

8 (22%

17 (20%)

15 (17%)

5 (least deprived)

7 (9%)

28 (33%)

17(20%)

Anxiety (PHQ) median (IQR)

3 (2–7)

3 (1–5)

3.5 (1–6.8)

Moderate/severe n (%)

3 (9%)

5 (6%)

10 (12%)

Missing

N = 1

N = 3

N = 3

Depression (GAD) (n = 202)

Median (IQR)

4 (3–10)

3 (1.5–6)

4 (2–7)

Moderate/severe n (%)

8 (23%)

13 (15%)

10 (12%)

Binge eating score 4

4 (11%)

8 (10%)

13 (17%)

Missing

N = 1

N = 3

N = 3

Living situation n (%)

Lives with partner

31 (84%)

67 (78%)

69 (79%)

Lives alone

3 (8%)

14 (16%)

17 (20%)

Lives in shared house

3 (8%)

5 (6%)

1 (1%)

Dependent children at home

25 (69%)

60 (73%)

59 (69%)

Highest education level n (%)

Primary & secondary

4 (11%)

15 (17%)

18 (21%)

Further

16 (43%)

22 (26%)

19 (22%)

Higher

16 (43%)

46 (57%)

47 (54%)

Missing

1 (3%)

3 (4%)

3 (3%)

Employment status n (%)

Full time

22 (60%)

61 (71%)

60 (69%)

Part time

7 (20%)

19 (22%)

23 (27%)

Unemployed/long term sick

4(10%)

2 (2%)

0 (0%)

Full time student

2 (5%)

2 (2%)

0 (0%)

Home carer

0 (0%)

2 (2%)

2 (2%)

Retired

2 (5%)

0 (0%)

2 (2%)

Any chronic health condition

29 (78%)

58 (68%)

60 (69%)

Anxiety/depression

5 (14%)

9 (10%)

8 (9%)

Musculoskeletal

9 (24%)

15 (17%)

17 (20%)

Asthma

2 (5%)

12 (14%)

5 (6%)

Gastrointestinal

2 (5%)

10 (12%)

8 (9%)

Thyroid

2 (5%)

5 (6%)

4 (5%)

Number of previous weight loss attempts

n (IQR)

3 (2–6)

4 (2–9)

4 (3–10)

≤2

12 (33%)

25 (29%)

20 (21%)

3–4

9 (24%)

21 (24%)

30 (35%)

5–9

4 (11%)

20 (23%)

14 (21%)

>9

12(33%)

21 (24%)

17 (20%)

Previously advised to lose weight by HCP

16 (43%)

42 (49%)

45 (52%)

Previous NHS weight loss programme

1 (3%)

9 (11%)

6 (7%)

Previous commercial weight loss programme

24 (65%)

61 (71%)

65 (75%)

  1. aFamily history of CVD: first degree relative who has had stroke, transient ischaemic attack, myocardial infarction, angina or peripheral vascular disease <age 60 years.
  2. bFamily history of T2D: First degree relative with T2D at any age.