Table 2 Prognostic performance of cellular dissociation grading (CGD), Brandwein–Gensler (BG) histopathological risk score, and WHO grading in the TCGA-HNSC cohort (n = 311) and in the subcohorts of HPV-negative (n = 286) and HPV-positive (n = 45) tumors.

Outcome	CDG (high vs. low)			BG score (high vs. int./low)			WHO grade (G3/G2 vs. G1)
Outcome	HR	CI	P	HR	CI	P	HR	CI	P
Univariate analysis
PFI	1.57	1.1–2.22	0.012	1.51	1.04–2.18	0.029	1.64	0.92–2.91	0.092
OS	1.64	1.19–2.26	0.0024	1.53	1.1–2.13	0.012	1.69	1.01–2.81	0.046
HPV−: PFI	1.4	0.96–2.03	0.08	1.42	0.96–2.12	0.081	1.63	0.91–2.92	0.097
HPV−: OS	1.48	1.05–2.08	0.025	1.38	0.96–1.97	0.079	1.69	1.01–2.83	0.047
HPV+: PFI	4.93	1.7–14.3	0.0034	2.71	0.87–8.42	0.084	NA^a	NA^a	NA^a
HPV+: OS	5.05	1.87–13.67	0.0014	3.95	1.37–11.44	0.011	NA^a	NA^a	NA^a
Multivariate analysis
PFI	1.55	1.05–2.28	0.028	1.49	1–2.23	0.051	1.18	0.64–2.19	0.6
OS	1.74	1.21–2.49	0.0026	1.48	1.03–2.13	0.033	1.43	0.81–2.52	0.22
HPV−: PFI	1.37	0.92–2.06	0.12	1.3	0.84–2.01	0.24	1.1	0.59–2.06	0.76
HPV−: OS	1.51	1.04–2.18	0.03	1.24	0.83–1.84	0.29	1.24	0.7–2.21	0.46
HPV+: PFI	3.46	0.82–14.56	0.09	2.07	0.46–9.37	0.34	NA^a	NA^a	NA^a
HPV+: OS	2.28	0.73–7.17	0.16	2.63	0.71–9.69	0.15	NA^a	NA^a	NA^a

Univariate analysis of DFI and OS and multivariate analysis of DFI and OS including age (>61 vs. ≤61 years), sex (female, male), HPV status (HPV-positive, HPV-negative), localization (oropharynx, all other), AJCC stage (I–III, IV), and margin status (negative/close, positive).
Bold fonts indicate statistical significance.
HR hazard ratio, CI 95% confidence interval.
^aAnalysis not feasible, because of low sample size (only a single tumor was HPV+ and G1).

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