Fig. 2: Evolutionary trees of ICCs.
From: Convergent genomic diversity and novel BCAA metabolism in intrahepatic cholangiocarcinoma
Ten evolutionary trees were constructed using the multi-region WES data with the Treeomics algorithm. Trunks, internal branches (int-Br) and external branches (ext-Br) generally correspond to ubiquitous, shared, and private mutations, respectively, whereas leaves correspond to the samples. The colours of the leaves are the same as the sample labels in Fig. 1 and Supplementary Fig. S2D. The lengths of the trunk and branches represent the number of mutations, and scales for ten mutations are shown near the roots of the evolutionary trees. Driver genes with possible functional mutations are mapped along the evolutionary trees. The image of each tumour is provided along with positions from which each sample was obtained. Red scale bars for one centimetre attempted with each photo.
