Table 2 Cox regression models for the associations between tumour necrosis percentage and survival in Cohorts 1 and 2.

  <3%

100

15

1 (referent)

1 (referent)

42

1 (referent)

1 (referent)

  3–9.9%

577

145

1.73 (1.01–2.94)

1.76 (1.02–3.04)

278

1.19 (0.87–1.65)

1.19 (0.85–1.66)

  10–39.9%

327

107

2.45 (1.43–4.20)

2.35 (1.34–4.11)

173

1.41 (1.01–1.97)

1.44 (1.02–2.04)

  ≥40%

59

28

4.24 (2.27–7.94)

3.22 (1.68–6.17)

37

1.96 (1.26–3.05)

1.88 (1.19–2.97)

  P_trend

<0.0001

<0.0001

0.0010

0.0011

  <3%

61

7

1 (referent)

1 (referent)

22

1 (referent)

1 (referent)

  3–9.9%

105

20

1.67 (0.71–3.94)

1.80 (0.71–4.60)

43

1.13 (0.68–1.89)

1.08 (0.62–1.88)

  10–39.9%

87

32

3.70 (1.63–8.39)

1.85 (0.75–4.55)

47

1.78 (1.07–2.94)

1.10 (0.62–1.96)

  ≥40%

31

17

7.53 (3.12–18.18)

3.39 (1.28–8.96)

21

3.14 (1.72–5.71)

1.70 (0.86–3.36)

  P_trend

<0.0001

0.018

<0.0001

0.19