Fig. 1: Flowchart of study design and methods.
From: Ovarian cancer pathology characteristics as predictors of variant pathogenicity in BRCA1 and BRCA2
Carriers refer to individuals with a reported germline pathogenic or likely pathogenic variant in BRCA1 or BRCA2. Non-carriers refer to individuals tested negative for BRCA1 and/or BRCA2 in germline. The ‘other’ category comprised rare forms of ovarian cancer not belonging to any of the other subtypes, including tumours defined as: ‘other’ by data sources not specifying tumour histology; mixed-epithelial carcinomas; carcinosarcomas, transitional cell (Brenner tumours), undifferentiated or poorly differentiated; squamous cell. HGSC high-grade serous carcinoma, LGSC low-grade serous carcinoma.
