Table 1 Baseline characteristics and adherence to treatment of the included 1175 women, stratified by tamoxifen dose.
Tamoxifen dose in mg | |||||||
|---|---|---|---|---|---|---|---|
Characteristic | All | 0 | 1 | 2.5 | 5 | 10 | 20 |
Number of women | 1175 | 202 | 193 | 194 | 188 | 199 | 199 |
Mean age at baseline, years (SD) | 55.7 (9.7) | 56.4 (9.7) | 54.5 (9.5) | 55.3 (9.9) | 55.5 (9.9) | 56.5 (10.0) | 55.9 (9.3) |
Number of premenopausal women (%) | 454 (38.6) | 70 (34.7) | 81 (42.0) | 76 (39.2) | 72 (38.3) | 76 (38.2) | 79 (39.7) |
Number of postmenopausal women (%) | 721 (61.4) | 132 (65.3) | 112 (58.0) | 118 (60.8) | 116 (61.7) | 123 (61.8) | 120 (60.3) |
Mean age at menopause, years (SD) | 50.0 (5.12) | 50.0 (4.78) | 50.0 (5.11) | 50.3 (5.66) | 49.6 (5.69) | 49.3 (4.61) | 50.4 (4.97) |
Mean age at menarche, years (SD) | 13.0 (1.36) | 13.2 (1.40) | 13.0 (1.39) | 12.8 (1.37) | 13.0 (1.32) | 13.1 (1.37) | 12.9 (1.32) |
Mean BMI (SD) | 25.4 (3.8) | 25.0 (3.6) | 25.5 (3.8) | 25.8 (4.3) | 25.6 (3.9) | 25.4 (3.7) | 25.4 (3.3) |
Mean number of pregnancies (SD) | 2.6 (1.6) | 2.5 (1.4) | 2.6 (1.6) | 2.8 (1.6) | 2.4 (1.6) | 2.5 (1.5) | 2.6 (1.7) |
Mean age at first birth, years (SD) | 28.8 (5.4) | 28.7 (5.5) | 28.8 (5.3) | 29.0 (5.3) | 28.7 (5.5) | 28.8 (5.5) | 28.9 (5.5) |
Number of current smokers (%) | 135 (12) | 17 (8) | 22 (11) | 18 (9) | 19 (10) | 26 (13) | 33 (17) |
Mean gram/week of alcohol last year (SD) | 49.4 (61.4) | 53.6 (64.7) | 48.9 (59.1) | 43.3 (43.9) | 49.4 (60.8) | 53.7 (81.8) | 47.5 (51.6) |
Adherence | |||||||
Compliant to treatmenta (%) | |||||||
All | 996 (85.3) | 182 (90.1) | 170 (88.5) | 159 (82.0) | 152 (82.2) | 164 (83.2) | 169 (85.8) |
Premenopausal | 393 (87.1) | 62 (88.6) | 71 (87.7) | 64 (84.2) | 64 (91.4) | 65 (85.5) | 67 (85.9) |
Postmenopausal | 603 (84.2) | 120 (90.9) | 99 (89.2) | 95 (80.5) | 88 (76.5) | 99 (81.8) | 102 (85.7) |
Number of women that discontinued treatment due to side effects (%) | |||||||
All | 132 (11.2) | 13 (6.4) | 15 (7.8) | 28 (14.4) | 27 (14.4) | 27 (13.6) | 22 (11.1) |
Premenopausal | 35 (7.7) | 4 (5.7) | 6 (7.4) | 6 (7.9) | 5 (6.9) | 7 (9.2) | 7 (8.9) |
Postmenopausal | 97 (13.5) | 9 (6.8) | 9 (8.0) | 22 (18.6) | 22 (19.0) | 20 (16.3) | 15 (12.5) |
