Fig. 5: Distribution of cytogenetic subtypes across four risk groups determined based on non-overlapping ranges of patient specific cumulative scores generated from the prognostic value of single genetic lesions. | British Journal of Cancer

Fig. 5: Distribution of cytogenetic subtypes across four risk groups determined based on non-overlapping ranges of patient specific cumulative scores generated from the prognostic value of single genetic lesions.

From: PersonALL: a genetic scoring guide for personalized risk assessment in pediatric B-cell precursor acute lymphoblastic leukemia

Fig. 5

a The excellent risk group almost exclusively comprised patients with ETV6/RUNX1 gene fusion or high-hyperdiploid (HHD) karyotype. b, c The good and the high-risk groups were dominated by patients who classified as B-other in the current study. d Two-thirds of the patients in the ultra-poor risk group carried BCR/ABL1 fusion or alterations characteristic of the Ph-like subtype, with an additional one-fifth of the children in this group harboring KMT2A rearrangement or iAMP21 genotype.

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