Table 2 Statistically significant results of the gene-environment interaction analyses for diabetes and single genetic variants for colorectal cancer risk.

From: Probing the diabetes and colorectal cancer relationship using gene – environment interaction analyses

Variant

Chr

BP position

Closest gene

Annotation

Reference allele

Alternate allele

Alternate allele frequency

Method

P (D|G)a

P (E|G)b

P (GxE)c

P-valued (Covariate set 1)e

P-valued (Covariate set 2)f

Primary GxE testing

rs3802177

8

118185025

SLC30A8

3’ UTR

G

A

0.31

3-d.f. joint test

4.05 × 10−01

4.90 × 10−10

7.49 × 10−04

5.46 × 10−11

1.01 × 10−10

Secondary GxE testing

rs9526201

13

47191972

LRCH1

intron

G

A

0.82

2-d.f. joint test

1.87 × 10−04

NA

1.33 × 10−06

7.84 × 10−09

8.82 × 10−09

  1. Chr chromosome, BP Position base pair position based on NCBI Build 37, d.f. degrees of freedom, UTR Untranslated region, NA not applicable.
  2. aP-value corresponds to the association between genetic variants and colorectal cancer.
  3. bP-value corresponds to the association between genetic variants and diabetes.
  4. cP-value corresponds to the interaction between genetic variants and diabetes on risk of colorectal cancer.
  5. dP-values correspond to each method used to test for interactions between genetic variants and diabetes.
  6. eCovariate set 1: age at baseline, sex, study, genotyping platform, and the first three principal components (Colorectal cancer cases = 31,318, Controls = 41,499).
  7. fCovariate set 2: covariate set 1 plus additional adjustment for body mass index.
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