Fig. 3: Texture-specific lymphocyte analysis.

a Lymphocyte proportion by textures. b Correlation matrix of the texture and texture-specific lymphocyte proportion. c Relative lymphocyte proportion (density normalised to 100%) by textures in individual patients (n = 447). The lymphocyte density (proportion/area) has been median-averaged by texture type and then their sum rescaled to 100%. d Correlation of relative lymphocyte proportion in malignant and normal renal tissue. e Lymphocyte proportion in cancer tissue by samples with or without normal tissue. f Association between clinical variables (binary variables) and texture-aware lymphocyte proportions (continuous variables). g Association between transcriptome-based signatures (binary variables) and texture-specific lymphocyte proportions (continuous variables). h Ploidy status (FALSE = aneuploidy, TRUE = normal) by lymphocyte infiltration in cancer tissue. i Heatmap of the normalised enrichment score of the significant gene pathways associated (adjusted p < 0.05) with lymphocyte infiltration to cancer or normal textures. Grey-coloured boxes indicate the pathways associated with only samples with or without normal tissue (adjusted p < 0.05). j Genes associated with lymphocyte infiltration to the cancer (red) or normal (blue) or both (green) texture. The coordinate of each dot represents the ratio of the gene expression value when comparing in (cancer or normal) texture-specific lymphocyte-rich vs. lymphocyte-low samples.