Fig. 5: Lymphocyte infiltration in the tumour margin.

a Lymphocyte proportion in the tumour margin by textures, and b comparison to the non-margin tissue. c Correlation matrix of the texture and texture-specific lymphocyte proportion in the tumour margin. d Relative lymphocyte proportion (density normalised to 100%) by textures in the tumour margin of individual patients. The lymphocyte density (proportion/area) has been median-averaged by texture type and then their sum rescaled to 100%. e Correlation of relative lymphocyte proportion in stromal margin and normal renal margin. f Correlation between the lymphocyte density in the cancer texture and tumour margin (TCGA dataset) and in the intratumoural and peritumoural regions (Helsinki dataset). Patients are divided by highest 25% (red) and lowest 75% (blue) cancer texture-specific lymphocyte density. g Association between clinical variables (binary variables) and the margin:non-margin ratio of lymphocyte proportion (continuous variables). h Enrichment of genomic alterations by margin:non-margin ratio of lymphocyte proportions in tissue textures. Only associations with p < 0.10 are visualised. i Normalised enrichment score (NES) of the gene pathways significantly associated with the ratio of margin:non-margin stroma proportion. j Comparison of the genes differentially-expressed in tumours with higher (right) or lower (left) margin lymphocyte density compared to non-margin lymphocyte density. k Association between transcriptome-based signatures (binary variables) and the margin:non-margin ratio of lymphocyte proportion (continuous variables).