Fig. 6: MiR-662 overexpression reduces global protein synthesis, enhancing stem-like traits of BC cells. | British Journal of Cancer

Fig. 6: MiR-662 overexpression reduces global protein synthesis, enhancing stem-like traits of BC cells.

From: MiR-662 is associated with metastatic relapse in early-stage breast cancer and promotes metastasis by stimulating cancer cell stemness

Fig. 6

a Heatmap showing expression levels of the 38 significantly deregulated DE-mRNAs (21 upregulated, 17 downregulated) in miR-662-overexpressing NW1 cells compared to mock-transfected cells obtained by RNA-seq. b Manual annotation of the 70 gene networks being affected by miR-662 overexpression in NW1 cells compared to mock-transfected cells obtained by GSEA analysis on RNA-seq data. Gene networks (represented as part of the whole) have been classified in 7 different groups, or reported as independent terms (8th group). c GSEA on RNA-seq data of gene networks involved in translation. Hallmark genes in translation were repressed by miR-662 overexpression compared to control cells. d GSEA of gene networks involved in ribosome biogenesis and rRNA processing. Hallmark genes were repressed by miR-662 overexpression compared to control cells. e GSEA of a gene network involved in mRNA splicing. Hallmark genes were repressed by miR-662 overexpression compared to control cells. f GSEA of a gene network that involves the MYC pathway and its targets. Hallmark genes were repressed by miR-662 overexpression compared to control cells.

Back to article page