Fig. 4: Repeated gas plasma exposure alters gene expression profiles in SCC-25 and A431 squamous cell carcinoma cells. | British Journal of Cancer

Fig. 4: Repeated gas plasma exposure alters gene expression profiles in SCC-25 and A431 squamous cell carcinoma cells.

From: Chronic oxidative stress adaptation in head and neck cancer cells generates slow-cyclers with decreased tumour growth in vivo

Fig. 4

a Volcano plot showing significantly up- (green) and downregulated (red) genes after single (n = 4) or repeated gas plasma exposure (n = 4) compared to untreated wild-type (n = 2) SCC-25 and A431 cells, statistical analysis was performed using moderate t test (two-tailed). b Top five protein classes and c top ten biological processes of significantly regulated genes independent of cell line. d Venn diagram showing differentially expressed genes for both cell lines after one single or multiple treatment cycles. e Two-tailed Pearson’s correlation of absolute gene expression fold change against toxicity (wild type) or viability (repeatedly exposed). f Log fold change of genes with a strong correlation in both SCC-25 and A431 cells, bar graphs show mean.

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