Fig. 1: CONSORT diagram of clinical trial.

Intention-to-treat population was 120 patients with metastatic colorectal cancer (mCRC), and per-protocol analysis involved 108 patients. Collection was from January 2018 to June 2020, and database was locked for final analysis on June 30, 2020. Median follow-up time was 26.5 months (interquartile range [IQR], 17.0ā37.0 months). Reversion to RAS wild-type by ctDNA testing was 0% during the cetuximab-based treatment.