Fig. 1: Determination and clinical features of polyploid HCCs. | British Journal of Cancer

Fig. 1: Determination and clinical features of polyploid HCCs.

From: Histological diagnosis of polyploidy discriminates an aggressive subset of hepatocellular carcinomas with poor prognosis

Fig. 1

a Multicolored chromosome FISH. Red, white and green dots indicate signals detecting chromosome 7, 11, 16, respectively. DAPI is shown in blue. Scale bars, 20 μm. b A violin plot of average chromosome numbers in each HCC. The copy numbers of three chromosomes per tumor cell nucleus were examined by evaluating more than 200 tumor nuclei at 5 or more high-magnification fields, and their predominant values were determined in each tumor. The average values of three stained chromosomes were plotted, and HCCs with 2.5 or more copies of chromosomes in average were defined as polyploid based on the bimodal distribution. c Serum AFP levels. d The main tumor size. Mann-Whitney U test in (c) and (d). Kaplan-Meier curves of overall survival (e) and disease-free survival (f). Error bars indicate mean ± SD.

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