Table 2 Hazard ratios (HR) for overall survival and progression-free survival in the presence of the different combinations of risk factors compared with patients without CTCs, low PD-L1+ sEV concentration and no ctDNA mutation (N = 51 patients with NSCLC without missing values for the three risk factors) (N = 51).
Risk factors | HR | 95% CI | P-value |
|---|---|---|---|
OS | |||
No risk factor | 1.00 | Ref | - |
CtDNA mutation only | 1.16 | (0.61; 2.21) | 0.649 |
CTCs only | 2.8 | (1.46; 5.39) | 0.002 |
PD-L1+ sEV concentration >11.5 pg/ml only | 2.73 | (1.36; 5.51) | 0.005 |
CTCs and PD-L1+ sEV concentration >11.5 pg/ml | 7.65 | (3.11; 18.83) | <0.001 |
CTCs and ctDNA mutation | 3.25 | (1.38; 7.65) | 0.007 |
PD-L1+ sEV concentration >11.5 pg/ml and ctDNA mutation | 3.17 | (1.09; 9.19) | 0.033 |
All the three risk factors | 8.88 | (2.79–28.31) | <0.001 |
PFS | |||
No risk factor | 1.00 | Ref | - |
CtDNA mutation only | 1.17 | (0.64; 2.16) | 0.607 |
CTCs only | 4.89 | (1.69; 14.2) | 0.003 |
PD-L1+ sEV concentration >8.6 pg/ml only | 4.23 | (1.61; 11.1) | 0.003 |
CTCs and PD-L1+ sEV concentration >8.6 pg/ml | 6.1 | (2.26; 16.46) | <0.001 |
CTCs and ctDNA mutation | 5.74 | (1.65; 19.95) | 0.006 |
PD-L1+ sEV concentration >8.6 pg/ml and ctDNA mutation | 4.96 | (1.47; 16.78) | 0.01 |
All the three risk factors | 7.15 | (2.04; 25.12) | 0.002 |
