Fig. 2: Longitudinal changes in serological immune responses to NY-ESO-1 and p53 in patients with positive preoperative antibody responses.

NY-ESO-1 antibody responses in 29 patients with recurrence (a) and in 56 patients without recurrence (b). The cut-off value of NY-ESO-1 antibody responses was an O.D. value of 0.5 at a serum dilution of 1:100. p53 antibody responses in 42 patients with recurrence (c) and in 71 patients without recurrence (d). The cut-off value of p53 antibody responses was 1.3 U/ml. Black lines indicate the data of patients whose antibody values did not fall below the cut-off level at 12 months, and gray lines indicate the data of patients whose antibody values fell below the cut-off level at 12 months. White and black wedges indicate the timing of recurrence within 1 year and after 1 year, respectively.